Niche Signals
Our research is particularly focused on how hepatocytes influence their own niche signals, specifically Wnt, which is produced by hepatic stellate cells and endothelial cells. Using advanced techniques such as single-cell RNA multiomics and spatial transcriptomics, we aim to map the dynamic changes in niche signals during liver injury and repair, identifying key regulatory nodes that can be targeted to enhance regenerative outcomes.
Polyploidy
Our research explores the mechanisms that regulate polyploid hepatocyte activation and division, with a particular focus on promoting their division rather than further polyploidization during chronic injury.
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